Prof.Won GuKim Korea (Republic of)

Prof.Won GuKim
Won Gu Kim, MD, PhD Professor, Department of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Prof. Kim is an endocrinologist whose research focuses on thyroid diseases, particularly thyroid cancer. His major interests include molecular biomarkers, tumor biology, and precision medicine. He has published more than 200 papers on thyroid research, encompassing both clinical and translational studies. He currently serves as the General Secretary of the Asia & Oceania Thyroid Association (AOTA) and has been actively involved in international collaborations in thyroid research. He also serves on the review boards of several leading journals, including Thyroid, European Thyroid Journal, Clinical Endocrinology, and Endocrinology & Metabolism.

22 MARCH

Time Session
11:00
12:30
[Symposium] Thyroid (5)
Novel Treatment and Diagnostic Approaches for Thyroid Cancer in Post-NGS Era
  • Advances in the Treatment of Radioactive Iodine-Refractory Differentiated Thyroid Cancer: Multikinase Inhibitors and Beyond – An Asian Perspective
    Won Gu KimKorea (Republic of) Speaker Advances in the Treatment of Radioactive Iodine-Refractory Differentiated Thyroid Cancer: Multikinase Inhibitors and Beyond – An Asian Perspective
  • The Genetic Landscape of Thyroid Cancer
    Young Joo ParkKorea (Republic of) Speaker Translating the Genetic Landscape of Thyroid Cancer to Precision Diagnosis and TherapyThyroid cancer is characterized by a relatively low mutational burden compared with other solid tumors, with recurrent alterations mainly involving BRAF, RAS, and various fusion genes. Several novel driver candidates have also been identified through next-generation sequencing studies. The frequency and pattern of these genomic alterations differ across thyroid cancer subtypes and are often associated with distinct histopathological phenotypes, providing valuable clues for differential diagnosis. Moreover, molecular subtypes defined by driver mutations are closely linked to tumor biology and clinical behavior, allowing more accurate prediction of disease aggressiveness and prognosis. Most differentiated thyroid cancers (DTCs) harbor a single dominant driver alteration; however, acquisition of additional mutations such as TERT promoter, tumor suppressor genes, or PI3K–AKT pathway alterations may lead to dedifferentiation and progression to aggressive or metastatic disease. Advances in our understanding of these genetic alterations have refined the pathological classification of thyroid cancer and enabled improved prognostication, treatment selection, and follow-up strategies. Importantly, the identification of actionable genetic alterations—including RET and NTRK fusions, as well as BRAF mutations—has revolutionized therapeutic approaches. Targeted agents such as selpercatinib, pralsetinib, larotrectinib, and entrectinib demonstrate substantial clinical efficacy with fewer adverse events than multikinase inhibitors, while dabrafenib plus trametinib has shown marked benefit in anaplastic thyroid cancer. With multiple targetable mutations being uncovered, incorporating comprehensive genomic testing into the diagnostic workflow is essential to guide precision therapy for patients with thyroid cancer.
  • Redifferentiation Strategies in Refractory Thyroid Cancer: First Insights from Taiwan
    He-Jiun JiangTaiwan Speaker Redifferentiation Strategies in Refractory Thyroid Cancer: First Insights from Taiwan
201BC