Prof. Miyuki Katai, MD, PhD
Professor and Director, Health Services Center, National Graduate Institute for Policy Studies (GRIPS), Tokyo, Japan
Prof. Miyuki Katai is an endocrinologist and a pioneer of sex- and gender-specific medicine (SGSM) in Japan. She earned her MD and PhD from Shinshu University, specializing in endocrinology. From 1998 to 2001, she worked as a research fellow at Harvard Medical School at Massachusetts General Hospital and the Joslin Diabetes Center, conducting basic research in endocrine and metabolic medicine. Recognizing that sex differences in health are largely driven by endocrine mechanisms, she has focused on integrating endocrinology and SGSM to promote personalized, evidence-based approaches to women’s health.
She served as Associate Professor of Gender Medicine and Women’s Internal Medicine at Tokyo Women’s Medical University (2007–2020) and is now Professor and Director at GRIPS, leading projects that combine endocrinology, gender medicine, gendered innovation, and digital health innovation. She also contributes to public policy and AI-driven research through government-funded initiatives, including the AMED-supported “WaiSE” project. This project is developing an AI-assisted diagnostic tool for women's health that implements a female-specific diagnostic algorithm based on symptoms, data, and endocrine parameters using the principles of SGSM. Prof. Katai currently serves as President of the Japanese Association for Gender-Specific Medicine and as a Board Member of the Japan Thyroid Association.
        
        
        
    
        
        21 MARCH
    
    
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                                                         08:30 
                            
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                                Precision Medicine in Endocrinology                             
                            
                            
                            
                                                            
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                                                            Shih-Li SuTaiwan
                                                            Speaker
                                                                                                                        Sex-Specific Approaches in Precision Medicine: Advancing Endocrinology CareSex differences are fundamental determinants of endocrine physiology and disease. Conventional approaches that treat men and women as biologically equivalent overlook variations in hormonal regulation, immune response, organ function, and pharmacologic metabolism. Precision medicine in endocrinology integrates these sex-specific biological and environmental factors to achieve individualized care.
Emerging evidence shows that women are more prone to autoimmune thyroid disease, prolactinoma, and osteoporosis, largely due to estrogen-enhanced immune activity and X-chromosome dosage effects. Men, by contrast, experience higher rates of hypogonadism, visceral obesity, and aggressive endocrine tumors, reflecting androgen decline and single X-chromosome vulnerability. Hormonal effects, such as menopause-related bone loss, are often reversible, whereas chromosomal influences—such as those seen in Turner and Klinefelter syndromes—are irreversible and genetically determined.
Pharmacokinetic and pharmacodynamic disparities further highlight the need for sex-informed dosing. Women generally have higher CYP3A4 activity and altered drug binding via increased sex hormone–binding globulin. In Asian populations, genetic polymorphisms, including the high prevalence of BRAF^V600E^ mutations in papillary thyroid cancer and variable androgen receptor CAG repeats, demand region-specific precision strategies.
Sex-specific precision endocrinology moves beyond a uniform model of care by recognizing biological sex as a key variable in disease risk and treatment response. Incorporating sex-stratified analyses, adjusted diagnostic thresholds, and personalized pharmacotherapy can enhance diagnostic accuracy and therapeutic safety. For Asia, integrating genetic and environmental diversity is essential to advance equitable, individualized endocrine care.
                                                                                                                     
                                                                                                     
                                                                                     
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                                                            Miyuki KataiJapan
                                                            Speaker
                                                                                                                        From the Bedside to the Digital World: Precision Medicine in Endocrinology with Al and ICT
                                                                                                                     
                                                                                                     
                                                                                     
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