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10:20
11:10
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(Mandarin Session)
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Lee-Ming ChuangTaiwan
Speaker
Understanding Biology of Type 2 Diabetes and Related Metabolic Disorders - In Memory of the Late Professor Tai Tong-YuanType 2 diabetes mellitus is one of the major non-communicable diseases and has a huge medical and societal impact in recent years and the years to come. Earlier understanding of diabetes is mainly from descriptive observations and epidemiological studies, albeit that the criteria of dysglycemia was only finally revised in year 2010 (ADA) & 2011 (WHO).
With advent of new technologies, research of diabetes has bloomed from molecular epidemiology to multi-omic studies. These advances have provided us an opportunity and challenge for better understanding and management of type 2 diabetes and related metabolic disorders.
Based on several different unbiased approaches, such as family-based genome-wide linkage analyses, genome-wide association studies, and mRNA differential display, we had been able to tease out certain candidate genes which are responsible disease processes, including insulin resistance, adipogenesis, obesity, and type 2 diabetes. I will illustrate translational medical studies of the genes from each of those approaches, such as Ribosome Binding Protein 1 (RRBP1), adiponectin (ADIPOQ), Vascular Adhesion Protein (VAP1), nocturnin (NOCT), and Prostaglandin Reductase 2 (PTGR2), respectively.
With the Stanford Asia–Pacific Program for Hypertension and Insulin Resistance (SAPPHIRe) cohort study, which was established in 1995, our ongoing studies not only provide us a better understanding of the genes/factors on metabolic disorders but also pave a path for developing potential treatment of insulin resistance and the related clinical disorders.
References.
1. Diabetes (2005) 54: 1200–1206
2. Journal of Biomedical Science (2023) 30:13
3. J Clin Endocrinol Metab (2001) 86: 3815–3819
4. EMBO Molecular Medicine (2025) 17:938-966
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