Prof.Lee-MingChuang Taiwan

Prof.Lee-MingChuang
Dr. Chuang received his MD in the National Taiwan University in 1978; and the Ph.D from the Graduate Institute of Clinical Medicine, National Taiwan University Medical College in 1987. He was trained as a reseach fellow on subject of insulin receptor signaling and cellular physiology under the mentoring of Dr. Ronald Kahn at the Joslin Diabetes Center and the Harvard Medical School at Boston, USA during 1991-1993. He was staff member of the department of internal medicine at the National Taiwan University Medical College since 1988. His research area covered both basic research on insulin action and clinical studies of insulin resistance related metabolic diseases. As one of the active principal investigators of collaborative studies such as the Stanford Asian-Pacific Program in Hypertension and Insulin Resistance (SAPPHIRe) and later to the TOPMed Program, he continued this work from molecular genetics to the multi-omics approaches to understanding traits of glucose insulin homeostasis, obesity and type 2 diabetes. In 2007 he was appointed as Distinguished Professor of Internal Medicine, National Taiwan Medical College. In 2015 he was appointed as Chair Professor of National Taiwan University based on his promient work on translational research in metabolic disease field. He has been author on more than 400 papers/artices in peer-reviewed journals. His dispine h-index is 78 and his articles have been cited more than 25,000 times.

21 MARCH

Time Session
10:20
11:10
(Mandarin Session)
  • Lee-Ming ChuangTaiwan Speaker Understanding Biology of Type 2 Diabetes and Related Metabolic Disorders - In Memory of the Late Professor Tai Tong-YuanType 2 diabetes mellitus is one of the major non-communicable diseases and has a huge medical and societal impact in recent years and the years to come. Earlier understanding of diabetes is mainly from descriptive observations and epidemiological studies, albeit that the criteria of dysglycemia was only finally revised in year 2010 (ADA) & 2011 (WHO). With advent of new technologies, research of diabetes has bloomed from molecular epidemiology to multi-omic studies. These advances have provided us an opportunity and challenge for better understanding and management of type 2 diabetes and related metabolic disorders. Based on several different unbiased approaches, such as family-based genome-wide linkage analyses, genome-wide association studies, and mRNA differential display, we had been able to tease out certain candidate genes which are responsible disease processes, including insulin resistance, adipogenesis, obesity, and type 2 diabetes. I will illustrate translational medical studies of the genes from each of those approaches, such as Ribosome Binding Protein 1 (RRBP1), adiponectin (ADIPOQ), Vascular Adhesion Protein (VAP1), nocturnin (NOCT), and Prostaglandin Reductase 2 (PTGR2), respectively. With the Stanford Asia–Pacific Program for Hypertension and Insulin Resistance (SAPPHIRe) cohort study, which was established in 1995, our ongoing studies not only provide us a better understanding of the genes/factors on metabolic disorders but also pave a path for developing potential treatment of insulin resistance and the related clinical disorders. References. 1. Diabetes (2005) 54: 1200–1206 2. Journal of Biomedical Science (2023) 30:13 3. J Clin Endocrinol Metab (2001) 86: 3815–3819 4. EMBO Molecular Medicine (2025) 17:938-966
  • Chin-Hsiao TsengTaiwan Speaker Research on Albuminuria in Taiwanese Patients with Type 2 Diabetes Mellitus
  • Wei-Shiung Yang Speaker
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