[Symposium] Obesity (2)
22 Mar 2026
11:00
12:30
101
Perspectives on Obesity in Asia-Oceania
Kathryn TanHong Kong, China
Moderator
Lipoprotein(a): What Endocrinologists Need to KnowLipoprotein(a) [Lp(a)] is a cholesterol-rich LDL-like particle with apolipoprotein(a) covalently linked to apolipoprotein B100 via a disulfide bond. Lp(a) is synthesized within the liver and there is a general inverse correlation between Lp(a) isoform size and plasma Lp(a) concentrations. About 90% of plasma Lp(a) concentration is genetically determined and plasma levels can modestly rise after menopause in women, and in conditions like hypothyroidism, nephrotic syndrome. It has been shown that elevated Lp(a) is an independent risk factor for atherosclerotic cardiovascular disease (ASCVD) and calcific aortic valve stenosis. Although Lp(a) concentration does vary with ethnicity, relationships between Lp(a) concentration and ASCVD risk remain similar across different ethnic groups. Elevated Lp(a) is considered a cardiovascular risk-enhancing or amplification factor, and recent guidelines and consensus have increasingly recommended universal screening for Lp(a). There are as yet, no approved therapies for elevated Lp(a). Current management focuses on intensifying control of concurrent risk factors, particularly LDL-C, to reduce ASCVD risk. Amongst existing lipid-lowering drugs, only proprotein convertase subtilisin/kexin type 9 inhibitors can lower Lp(a) levels modestly. Emerging RNA-based and small-molecule therapeutics are under development and are showing promising Lp(a)-lowering effects up to 80-90%. Ongoing phase 3 cardiovascular outcomes trials will determine whether effectively lowering Lp(a) can translate to cardiovascular benefit.
| Time | Session |
|---|---|
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11:00
11:30
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Vivien LimSingapore
Speaker
The Danger of Obesity in South East Asia and Practical Tips in the Clinic Obesity is steadily increasing in South East Asia (SEA) and with it comes complications naturally follow from it - metabolic, physical and mental. The talk will touch on the following:
- the prevalence of this and the changes over time
- the rising burden of it
- practical tips that can aid in the clinic including busting myths and misconceptions that hamper its management
101
|
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11:30
12:00
|
101
|
|
12:00
12:30
|
101
|