The increasing popularity of disposable vapes among Filipino youth has raised health concerns about their impact on major organ systems. While preclinical studies have primarily focused on pulmonary injury, growing evidence also points to potential liver involvement, a key metabolic and detoxifying organ, though human evidence on vaping-related liver impact remains limited. Despite being marketed as a safer alternative to traditional cigarettes, emerging evidence suggests that chronic exposure to vape aerosols may cause oxidative stress and hepatocellular injury. This study examined the effects of disposable vaping on oxidative stress and liver integrity by measuring levels of Malondialdehyde (MDA), Alanine Transaminase (ALT), and Aspartate Transaminase (AST) among selected young adult disposable vape users in Dumaguete City, Philippines.

A descriptive-comparative-correlational design was used, involving respondents aged 18-25 who used disposable vapes daily for at least 12 months. MDA levels were assessed using the Thiobarbituric Acid (TBA) Method, while ALT and AST levels were determined using enzymatic spectrophotometric assays. Data were analyzed using SPSS, using Spearman's rho to explore correlations between daily vaping frequency and biomarker levels.

Results revealed elevated MDA, ALT, and AST levels in a notable portion of respondents, with higher values generally observed in males. Correlation analysis showed association between vaping frequency and MDA levels, a positive correlation with ALT, and a correlation with AST.

These findings suggest a potential link between frequent disposable vape use and early signs of oxidative stress and hepatocellular injury, highlighting the need for further investigation and stronger public health measures.