Thyroid nodules can be evaluated using TIRADS Score base on morphological aspects on ultrasonography (USG) or base on functional aspects on thyroid scintigraphy. These two modalities are complementary, but the results of these two modalities are not always concordant, which can affect clinical decisions. Data regarding the concordance of these two modalities in Indonesia remains limited. This study aims to compare thyroid scintigraphy findings with TIRADS scores and the correlation with serum TSHs level.

This comparative descriptive study was conducted retrospectively at the Department of Nuclear Medicine and Molecular Theranostic, Dr. Hasan Sadikin General Hospital Bandung from June 2024 to July 2025. Subjects were patients with thyroid nodules identified by USG. Subjects who met the inclusion and exclusion criteria underwent thyroid scintigraphy. Total sampling was used. Data were analyzed descriptively (mean ± SD for numerical data, n (%) for categorical data) and inferentially using Fisher’s Exact Test based on the Chi-square assumptions that was not met.

A Total of 57 subjects were included in this study. The mean age of the subjects was 41.49 ± 16.73 years with 89.5% of subjects were female. Subjects with TIRADS 1, 2, 3, 4 and 5 were 7 (12.3%), 10 (17.5%), 13 (22.8%), 23 (40.4%), and 4 (7.0%) respectively. Subjects with cold nodules were 39 (68.4%). Subjects with normal thyroid function (euthyroid) were 39 (68.4%). There was no significant association between nodule characteristics on thyroid scintigraphy and TIRADS scores (p = 0.747), but there was a significant association between nodule characteristics on thyroid scintigraphy and TSHs levels (p = 0.007). Thyroid function parameters (TSH levels and scintigraphic findings) are generally correlated however, the morphological features assessed by ultrasonography (TIRADS classification) do not always parallel the functional activity of the nodules.

There was a significance association between nodule characteristics on thyroid scintigraphy with TSH levels , but not with TIRADS scores. These findings provide preliminary insight; however, studies with larger sample sizes are needed to strengthen the evidence.