- AOCE 2026

Submission Status

Submitted

Abstract Submission

Abstract Title

Cyclin D1 Overexpression in Sporadic Primary Hyperparathyroidism: Immunohistochemical Insights from a Taiwanese Cohort

Presentation Type

Oral Presentation

Type Reference

Scientific Research Abstract

Abstract Category

Bone and Calcium/Parathyroid

Author's Information

Number of Authors (including submitting/presenting author) *

8

No more than 15 authors can be listed (as per the Good Publication Practice (GPP) Guidelines).
Please ensure the authors are listed in the right order.

Co-author 1

Yu-Yun Su skatrinau425@gmail.com Mackay Memorial Hospital Division of Endocrinology and Metabolism, Department of Internal Medicine Taipei Taiwan *

Co-author 2

Shuen-Han Dai lola102276@gmail.com Mackay Memorial Hospital Department of Pathology Taipei Taiwan -

Co-author 3

Che-Ning Chang inuyashasteven1231@gmail.com Mackay Memorial Hospital Department of Family Medicine Taipei Taiwan -

Co-author 4

Shih-Ping Cheng t119@mmu.edu.tw Mackay Memorial Hospital Division of General Surgery, Department of Surgery Taipei Taiwan -

Co-author 5

Chiao-Ya Chan jessie8315247@gmail.com Mackay Memorial Hospital Division of Endocrinology and Metabolism, Department of Internal Medicine Taipei Taiwan -

Co-author 6

Ming-Nan Chien mingnan@mmh.org.tw Mackay Memorial Hospital Division of Endocrinology and Metabolism, Department of Internal Medicine Taipei Taiwan -

Co-author 7

Chun-Chuan Lee lee5957.5957@mmh.org.tw Mackay Memorial Hospital Division of Endocrinology and Metabolism, Department of Internal Medicine Taipei Taiwan -

Co-author 8

Ming-Chieh Tsai* r07849036@ntu.edu.tw Mackay Memorial Hospital Division of Endocrinology and Metabolism, Department of Internal Medicine Taipei Taiwan -

Co-author 9

-

Co-author 10

-

Co-author 11

-

Co-author 12

-

Co-author 13

-

Co-author 14

-

Co-author 15

-

Abstract Content

Background and aims *

Cyclin D1 (CCND1) is a key regulator of cell cycle progression and has been implicated in the tumorigenesis of sporadic primary hyperparathyroidism (PHPT). However, molecular data from Asia-Pacific populations remain limited. This study aimed to evaluate cyclin D1 expression in parathyroid adenomas from Taiwanese patients with sporadic PHPT.

Methods *

This retrospective single-center cohort study was conducted at MacKay Memorial Hospital, Taiwan, between 2020 and 2024. We collected formalin-fixed, paraffin-embedded (FFPE) parathyroid adenoma specimens from 52 patients with sporadic PHPT who underwent parathyroidectomy. Control samples consisted of histologically normal parathyroid tissue, incidentally removed during total thyroidectomy performed as part of thyroid cancer treatment. Cyclin D1 expression was assessed by immunohistochemistry and quantified as the percentage of positively stained cells.

Results *

Cyclin D1 expression was significantly higher in PHPT adenomas (mean 59.3%, SD 31.6) than in control tissue (mean 17.0%, SD 9.7; p < 0.001).

Conclusions *

Cyclin D1 expression is increased in parathyroid adenomas from Taiwanese patients with sporadic PHPT. These findings provide molecular evidence from the underrepresented Asia-Pacific region and may contribute to a broader understanding of PHPT pathogenesis.

Keyword(s)

Figure 1

https://storage.unitedwebnetwork.com/files/1305/db0b20c8a1705c3c92fa7b9bfc30cac3.png

Figure 1 Caption

Total Word Count

179

Presenting Author First Name

Yu-Yun

Presenting Author Last Name

Su

Presenting Author Email

skatrinau425@gmail.com

Country (Internal Use)

Presentation Details

Session

Oral Presentation 4: Metabolic Synergy: Diabetes & Obesity Management

Date

Mar. 21 (Sat.)

Time

10:29 - 10:38

Presentation Order

02