Obesity is a multifactorial chronic disease associated with significant cardiometabolic and psychosocial burden. Its management requires a personalized, multidisciplinary approach that addresses medical, nutritional, and behavioral aspects. The Cipto Mangunkusumo National Referral Hospital established an Integrated Obesity Clinic (IOC) to provide coordinated, multi-specialist care. This study aimed to describe the early clinical outcomes of the IOC program.

This prospective case series included 26 adults with obesity (mean age 37 years, mean BMI 45.1 kg/m²) managed between February 2023 and July 2024. All patients underwent baseline assessments by endocrinology, clinical nutrition, and physical medicine specialists, with additional referrals as required. Interventions included lifestyle modification, pharmacotherapy (GLP-1 receptor agonists, metformin, or combination therapy), intragastric balloon placement (n = 6), and bariatric surgery (n = 4). Body weight and BMI were recorded at baseline and at 4–6-month follow-up. The primary outcome was percentage weight reduction from baseline.

Mean baseline body weight was 142.0 kg, which decreased to 125.8 kg after 4–6 months, representing a mean reduction of 12.5 kg (8.9%). Clinically significant weight loss (≥5%) was achieved by most participants. Greater reductions were observed among patients who underwent intragastric balloon or bariatric surgery compared with those receiving medical therapy alone. The main barriers identified were suboptimal adherence and limited financial coverage within the national insurance system.

The Integrated Obesity Clinic model at Indonesia’s national referral hospital achieved a mean 9% body-weight reduction within six months, exceeding the threshold for metabolic improvement. These findings highlight the feasibility and potential benefits of multidisciplinary obesity management. Expansion of this model within the National Health Insurance system could improve access to effective obesity care and reduce related morbidity and mortality nationwide.