Metabolic disorders has surfaced as a critical worldwide health problem. This intricate condition is shaped by Genetic, Environmental and Life-Style influences, notably affected by Time Restricted Dietary Approaches. This study aspires to illuminate the intricate relationship between obesity-related genetic/biochemical factors, the practice of time restricted eating and the emergence of Obesity, alongside the relevance of various metabolic diseases.

A total of 300 Individuals diagnosed with Type-2 Diabetes, Aged between 18 to 60 years, were enrolled in the clinical outpatient department of General Medicine at King George’s Medical University. We conducted assessment of Fasting Blood Glucose and Postprandial levels, Lipid Profile, HBA1c, hormonal Levels along with 48 hours Ambulatory Blood Pressure Monitoring. Additionally we analyzed Genetic Expression Utilizing RT-PCR Techniques.

When we compared these 3 groups, Significant Different parameters found in FBG (P = 0.01) Postprandial (P = 0.03) HbA1c (P = 0.001) TG (P = 0.0001), Total Cholesterol (P = 0.01) & VLDL (P = 0.005). It also shows the complete inversion of the cortisol level (0.003). Insulin, IL-1 beta & IL-6 also show significant change in late night eating T2DM Patients. Systolic / Diastolic readings of ABPM shows significant change between MC and IC (0.005) but not b/w EC & IC (0.007). And for reliability of sleep by actigraphy shows MC (6:15 + 1:35) & EC (8:18 + 1:23) take complete sleep but IC total sleep hours (5:10 + 1:05) are very less. Disruption of Rev Erb & Ror α gene expression is also a risk factor for Cardio metabolic Diseases in T2DM Patients.

By comprehending the complex interplay between biochemical, genetics, time restricted dietary patterns and the onset of obesity, this research underscores the necessity of a holistic strategy that takes into account genetic tendencies in conjunction with environmental factors, which is vital for crafting effective prevention and treatment strategies, therapy enhancing health outcomes across various populations/diverse communities. .