Background Thyroid disorders are among the most common endocrine abnormalities, yet their systemic manifestations often overshadow subtle but clinically significant urological consequences. From bladder dysfunction to sexual health and renal physiology, thyroid hormones play a pivotal role in genitourinary homeostasis. However, this intersection remains under-explored in clinical practice. This study aims to evaluate the prevalence, pathophysiological mechanisms, and clinical outcomes of thyroid dysfunction–related urological manifestations.

Objectives 1. To assess lower urinary tract symptoms (LUTS) and sexual dysfunction in patients with thyroid disorders. 2. To analyze hormonal and metabolic correlations influencing renal and urological physiology. 3. To establish a multidisciplinary screening approach for early detection of thyroid-linked urological conditions.

Results Hypothyroid group: 64% exhibited significant LUTS with mean Qmax reduction of 25%. Hyperthyroid group: 42% showed irritative symptoms, including frequency and urgency, mimicking overactive bladder. Sexual dysfunction: Noted in 58% of males and 46% of females with thyroid dysfunction, correlating strongly with elevated TSH (p < 0.001). Renal function: Subclinical hypothyroidism demonstrated mild reversible elevations in serum creatinine, suggesting metabolic modulation of renal hemodynamics.

Conclusion This study underscores the often-overlooked endocrine–urologic axis, emphasizing that thyroid dysfunction should be a differential consideration in patients presenting with bladder or sexual symptoms. Collaboration between endocrinologists and urologists can optimize outcomes through comprehensive evaluation and integrated therapy.